By Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov

ISBN-10: 1439819068

ISBN-13: 9781439819067

"A mirrored image of the serious examine of the results of electromagnetic fields on residing tissues that has taken position over the last a number of many years, this ebook discusses the theoretical and experimental proof and concerns the results of sturdy electromagnetic fields and/or electrical pulses and their significance in drugs and biology. The authors current the fundamental strategies utilized in electroporation and the complicated equipment for construction of nanopores, highlighting their uncomplicated technology and scientific functions. themes comprise nano electroporation, vintage electroporaiton, experimental facts for electroporation of residing cells, and electroporation for melanoma and wound healing"--Provided through writer. learn more... content material: fundamentals of Electroporation actual Chemical concept of Membrane Electroporation and Electrotransfer of Biogenic brokers, E. Neumann and S. Kakorin Bioelectric impression of extreme Nanosecond Pulses, K.H. Schoenbach brought on Transmembrane Voltage-Theory, Modeling, and Experiments, T. Kotnik and G. Pucihar Electroporation: A evaluation of easy difficulties in concept and scan, M.S. Markov Mechanisms of Electroporation in Lipid platforms Electrodeformation, Electroporation, and Electrofusion of Cell-Sized Lipid Vesicles, R. Dimova Fluorescent tools in assessment of Nanopore Conductivity and Their Computational Validation, M. Kotulska, W. Dyrka, and P. Sadowski Electroporation of Lipid Membranes: Insights from Molecular Dynamics Simulations, M. Tarek and L. Delemotte Nanoscale Restructuring of Lipid Bilayers in Nanosecond electrical Fields, P.T. Vernier Mechanisms of Electroporation of Cells Nanopores: a different Transmembrane Passageway in Electroporated Cells, A.G. Pakhomov and O.N. Pakhomova version of phone Membrane Electroporation and Transmembrane Molecular shipping, D. Miklavcic and L. Towhidi Kinetics of Pore Formation and Disappearance within the phone in the course of Electroporation, G. Saulis the heart beat Intensity-Duration Dependency for mobile Membrane Electroporation, D. Miklavcic, G. Pucihar, A.M. Lebar, J. Krmelj, and L. Towhidi Mechanisms of Electroporation in Tissues Drug-Free, good Tumor Ablation by way of Electroporating Pulses: Mechanisms That Couple to Necrotic and Apoptotic phone dying Pathways, A.T. Esser, K.C. Smith, T.R. Gowrishankar, and J.C. Weaver Gene Electrotransfer: From easy procedures to Preclinical purposes, J.-M. Escoffre, A. Paganin-Gioanni, E. Bellard, M. Golzio, M.-P. Rols, and J. Teissie Technical issues Modeling electrical box Distribution In Vivo, N. Pavselj, A. Zupanic, and D. Miklavcic recommendations of Electroporation Pulse iteration and assessment of electrical Pulse turbines for cellphone and Tissue Electroporation, M. Rebersek and D. Miklavcic iteration of Ultrashort Pulses, J.F. Kolb Nanosecond Pulsed electrical box supply to organic Samples: problems and power suggestions, A. Silve, J. Villemejane, V. Joubert, A. Ivorra, and L.M. Mir functions of Electroporation Translation of Electroporation-Mediated DNA supply to the sanatorium, L.C. Heller and R. Heller scientific Electrochemotherapy: The Italian event, C.R. Rossi and L.G. Campana Tumor Blood Flow-Modifying results of Electroporation and Electrochemotherapy-Experimental facts and Implications for the treatment, T. Jarm, M. Cemazar, and G. Sersa lectrochemotherapy as a part of an Immunotherapy approach within the remedy of melanoma, J. Gehl ombined electric box and Ultrasound: A Nondrug-Based process for Tumor Ablation, P.F. Forde, C. Twomey, G.C. O' Sullivan, and D. M. Soden mixed Modality treatment: Electrochemotherapy with Tumor Irradiation, G. Sersa, S. Kranjc, and M. Cemazar Irreversible Electroporation in drugs, B. Rubinsky meals and Biomaterials Processing Assisted by way of Electroporation, N. Lebovka and E. Vorobiev In Vivo Electroporation: a huge damage Mechanism in electric surprise Trauma, I. Barakat, J. Gallaher, H. Chen, and R.C. Lee Index summary: Reflecting the serious examine of the consequences of electromagnetic fields on residing tissues that has taken position through the years, this name summarizes the experimental findings and theories on the topic of permeabilization of biomembranes through pulsed electrical fields. it really is meant generally for biomedical and actual scientists, engineers, and clinicians. learn more...

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2006) requires that the electrodes are brought into close contact with the treated tissue. This limits the application to treatments of tissue close to the surface of the body. The use of antennas, on the other hand, would allow one to apply such electric fields to tissues (tumors) that are not easily accessible with needles. Also, the focusing of electrical energy on the target would reduce the damage to the tissue layers surrounding the target and the skin. The spatial resolution of an electric field generated in tissue depends on the pulse duration and the permittivity of the tissue.

Lab. , 131, 1517–1524. R. , 1995, Dielectric properties of tissues, in Handbook of Biological Effects of Electromagnetic Fields, Polk, C. , CRC Press, Boca Raton, FL, p. 90, Fig. 28. , 2006, Plasma membrane voltage changes during nanosecond pulsed electric field exposure, Biophys. , 90, 3608–3615. , 2007, In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies, Int. J. Cancer, 121, 675–682. Ghazala, A. , 2000, Biofouling prevention with pulsed electric fields, IEEE Trans.

17 Aggregation of platelets plotted versus the similarity parameter, Eτ N (electric field intensity times pulse duration time square root of the number of pulses) for pulses with duration of 60 and 300 ns. H. , IEEE Trans. Dielect. Electr. , 14, 1088, 2007. 18 (a) Trypan blue exclusion for B16 cells versus the scaling parameter Eτ N . The number of pulses in the 800 ps experiment was varied between 1 and 20,000, the number in the 10 ns experiment, between 50 and 200. 18a). The results show that trypan blue exclusion is not a dose effect.

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